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Article

Effect of caloric restriction on Hprt lymphocyte mutation in aging rats.

Mutation research - 19 Jun 2003

Aidoo Anane, Mittelstaedt Roberta A, Bishop Michelle E, Lyn-Cook Lascelles E, Chen Yi-Ju, Duffy Peter, Heflich Robert H

Abstract excerpt

Caloric restriction (CR) reduces tumor incidence and retards aging in laboratory animals, including non-human primates. Because of the relationships among mutation, disease susceptibility, and aging, we investigated whether or not CR affects the accumulation of somatic cell mutations in aging animals. Starting at approximately 2 months of age, male CD rats (Harlan Sprague-Dawley-derived) were placed on different...

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Identifiers

PMID: 12787914
DOI: 10.1016/s0027-5107(03)00072-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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