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Article

EGF shifts human airway basal cell fate toward a smoking-associated airway epithelial phenotype

1 Jul 2013

Abstract excerpt

The airway epithelium of smokers acquires pathological phenotypes, including basal cell (BC) and/or goblet cell hyperplasia, squamous metaplasia, structural and functional abnormalities of ciliated cells, decreased number of secretoglobin (SCGB1A1)-expressing secretory cells, and a disordered junctional barrier. In this study, we hypothesized that smoking alters airway epithelial structure through modification of...

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PMID: 23818594
DOI: 10.1073/pnas.1303058110

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