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Article

Cytochrome p450 3A4 messenger ribonucleic acid induction by rifampin in human peripheral blood mononuclear cells: correlation with alprazolam pharmacokinetics.

Clinical pharmacology and therapeutics - 1 Nov 2003

Gashaw Isabella, Kirchheiner Julia, Goldammer Mark, Bauer Steffen, Seidemann Julia, Zoller Konrad, Mrozikiewicz Przemyslaw M, Roots Ivar, Brockmöller Jürgen

Abstract excerpt

OBJECTIVE: There is significant interest in the assessment of the individual cytochrome p450 (CYP) 3A4 activity. We analyzed whether CYP3A4 messenger ribonucleic acid (mRNA) concentrations in leukocytes reflect CYP3A activity in the liver measured by alprazolam as an in vivo probe drug. We also w...

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Identifiers

PMID: 14586385
DOI: 10.1016/S0009-9236(03)00237-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-14586385-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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