Article
Different Inductive Effects of Praziquantel Racemate and its Enantiomers on the Enzyme CYP3A4 Mediated by Pregnane X Receptor and its Variants.
Current drug metabolism - 1 Jan 2021
Meng Ran, Zhang Xueli, Wang Haina, Zhang Danlu, Zhao Xin
Abstract excerpt
BACKGROUND: Praziquantel (PZQ), which possesses an asymmetric center, is classified as a pyrazinoisoquinoline and has been the mainstay in the treatment of schistosomiasis since 1980. PZQ undergoes a pronounced first-pass metabolism in the liver through the CYP450 system which could be mediated by nuclear receptors. OBJECTIVE: The purpose of this study was to investigate the possible different induction effects...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.