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Article

Dissecting the functional domain requirements of cortactin in invadopodia formation.

European journal of cell biology - 1 Apr 2007

Webb Bradley A, Jia Lilly, Eves Robert, Mak Alan S

Abstract excerpt

Cells degrade extracellular matrix (ECM) barriers at focal locations by the formation of membrane protrusions called invadopodia. Polymerization of the actin cytoskeleton is critical to the extension of these processes into the ECM. We used a short interference RNA/rescue strategy to investigate the role of cortactin in the formation of Src-induced invadopodia in 3T3 fibroblasts, and subsequent degradation of the...

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Identifiers

PMID: 17343955
DOI: 10.1016/j.ejcb.2007.01.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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