Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Irreversibility of cellular senescence: dual roles of p16INK4a/Rb-pathway in cell cycle control

7 Mar 2007

Abstract excerpt

The retinoblastoma (Rb) tumor suppressor gene product, pRb, has an established role in the implementation of cellular senescence, the state of irreversible G1 cell cycle arrest provoked by diverse oncogenic stresses. In murine cells, senescence cell cycle arrest can be reversed by subsequent inactivation of pRb, indicating that pRb is required not only for the onset of cellular senescence, but also for the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Epigenetics and DNA Methylation
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17343761
DOI: 10.1186/1747-1028-2-10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Irreversibility of cellular senescence: dual roles of p16INK4a/Rb-pathway in cell cycle controlPMID 17343761Read ↗

Is Senescence Reversible?Semantic proximity Read ↗

The specific role of pRb in p16<sup>INK4A</sup>-mediated arrest of normal and malignant human breast cellsSemantic proximity Read ↗

Differential Roles for Cyclin-Dependent Kinase Inhibitors p21 and p16 in the Mechanisms of Senescence and Differentiation in Human FibroblastsSemantic proximity Read ↗

p16INK4a and the control of cellular proliferative life spanSemantic proximity Read ↗

Loss of retinoblastoma but not p16 function allows bypass of replicative senescence in human fibroblastsSemantic proximity Read ↗

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblastsSemantic proximity Read ↗

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblastsSemantic proximity Read ↗

Role of the Retinoblastoma Protein in Differentiation and SenescenceSemantic proximity Read ↗

A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy.Semantic proximity Read ↗

Regulation of a Senescence Checkpoint Response by the E2F1 Transcription Factor and p14 <sup>ARF</sup> Tumor SuppressorSemantic proximity Read ↗

Cellular senescence in naevi and immortalisation in melanoma: a role for p16?Semantic proximity Read ↗

A G1 checkpoint mediated by the retinoblastoma protein that is dispensable in terminal differentiation but essential for senescence.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.