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Growth inhibition of colon cancer cells by transfection of dominant-negative apoptosis signal-regulating kinase-1.

Oncology reports - 1 Apr 2007

Kuwamura Hikaru, Tominaga Kazunari, Shiota Masayuki, Ashida Reiko, Nakao Takafumi, Sasaki Eiji, Watanabe Toshio, Fujiwara Yasuhiro, Oshitani Nobuhide, Higuchi Kazuhide, Ichijo Hidenori, Arakawa Tetsuo, Iwao Hiroshi

Abstract excerpt

Apoptosis signal-regulating kinase-1 (ASK-1) is an important molecule for the pro-apoptotic signaling. ASK-1 also contributes to the cellular survival for many types of cells. Thus, ASK-1 has a broad range of biological activities depending on the cell type. The present study assessed the role(s) of ASK-1 in colorectal cancer cells (HT-29) by using adenovirus vectors expressing wild-type (WT)-ASK-1 or...

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PMID: 17342315

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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