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Article

The BH3-only protein PUMA is involved in green tea polyphenol-induced apoptosis in colorectal cancer cell lines.

Cancer biology & therapy - 1 Jun 2008

Wang Xi, Wang Rui, Hao Miao-Wang, Dong Ke, Wei San-Hua, Lin Fang, Ren Ji-Hong, Zhang Hui-Zhong

Abstract excerpt

The green tea polyphenol (GTP) has been shown to possess cancer therapeutic effect through induction of apoptosis, while the underlying molecular mechanism of its anticancer effect is not well understood. PUMA (p53-upregulated modulator of apoptosis) plays an important role in the process of apoptosis induction in a variety of human tumor cells in both p53-dependent and -independent manners. However, whether or...

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PMID: 18367875
DOI: 10.4161/cbt.7.6.5911

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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