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Article

Suppression of apoptosis signal-regulating kinase 1-induced cell death by 14-3-3 proteins.

Proceedings of the National Academy of Sciences of the United States of America - 20 Jul 1999

Zhang L, Chen J, Fu H

Abstract excerpt

Apoptosis signal-regulating kinase 1 (ASK1) is a pivotal component of a signaling pathway induced by many death stimuli, including tumor necrosis factor alpha, Fas, and the anticancer drugs cisplatin and paclitaxel. Here we report that ASK1 proapoptotic activity is antagonized by association with 14-3-3 proteins. We found that ASK1 specifically bound 14-3-3 proteins via a site involving Ser-967 of ASK1....

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Identifiers

PMID: 10411906
DOI: 10.1073/pnas.96.15.8511
PMCID: PMC17547

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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