Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Haplotype effects on matrix metalloproteinase-1 gene promoter activity in cancer cells.

Molecular cancer research : MCR - 1 Mar 2007

Pearce Eve G, Laxton Ross C, Pereira Andresa C, Ye Shu

Abstract excerpt

Increased expression of matrix metalloproteinase-1 (MMP1) is associated with poor prognosis in cancers. Several single nucleotide polymorphisms (-1607GG>G, -839G>A, -755G>T, -519A>G, -422T>A, -340C>T, and 320C>T) in the MMP1 gene promoter have recently been identified. In this study, we assessed the functional effects of these polymorphisms on MMP1 gene promoter activity in cell lines of melanoma (A2058 and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Gene Expression Regulation, Enzymologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Gene Frequency

Share to Matrix Metalloproteinase 1

Share to Neoplasms

Share to Polymorphism, Genetic

Share to Promoter Regions, Genetic

Source

Identifiers

PMID: 17339606
DOI: 10.1158/1541-7786.MCR-06-0139

Genes

MMP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Haplotype effects on matrix metalloproteinase-1 gene promoter activity in cancer cells.PMID 17339606Read ↗

Functional haplotypes in the promoter of matrix metalloproteinase-2 predict risk of the occurrence and metastasis of esophageal cancer.Semantic proximity Read ↗

Influence of single nucleotide polymorphisms in the MMP1 promoter region on cutaneous melanoma progression.Semantic proximity Read ↗

Promoter polymorphisms in matrix metallopeptidase 1 and risk of cutaneous melanoma.Semantic proximity Read ↗

Functional haplotypes in the promoter of matrix metalloproteinase-2 and lung cancer susceptibility.Semantic proximity Read ↗

Polymorphisms in the promoter regions of matrix metalloproteinases 1 and 3 and cancer risk: a meta-analysis of 50 case-control studies.Semantic proximity Read ↗

Haplotypes in matrix metalloproteinase gene cluster on chromosome 11q22 contribute to the risk of lung cancer development and progression.Semantic proximity Read ↗

Prognostic significance of MMP-1 and MMP-3 functional promoter polymorphisms in colorectal cancer.Semantic proximity Read ↗

Matrix metalloproteinase single-nucleotide polymorphisms and haplotypes predict breast cancer progression.Semantic proximity Read ↗

The influence of functional polymorphisms in matrix metalloproteinase 9 on survival of breast cancer patients in a Chinese population.Semantic proximity Read ↗

A functional polymorphism in the matrix metalloproteinase-1 gene promoter is associated with susceptibility and aggressiveness of head and neck cancer.Semantic proximity Read ↗

Association of single nucleotide polymorphisms in promoter of matrix metalloproteinase-2, 8 genes with bladder cancer risk in Northern India.Semantic proximity Read ↗

Single nucleotide polymorphisms in MMP1 and MMP3 gene promoters as risk factor in head and neck squamous cell carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.