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Article

Functional haplotypes in the promoter of matrix metalloproteinase-2 and lung cancer susceptibility.

Carcinogenesis - 1 Jun 2005

Zhou Yifeng, Yu Chunyuan, Miao Xiaoping, Wang Yonggang, Tan Wen, Sun Tong, Zhang Xuemei, Xiong Ping, Lin Dongxin

Abstract excerpt

Matrix metalloproteinase-2 (MMP-2) plays important roles in cancer initiation and progression. Our previous studies revealed that the -1306C-->T and -735C-->T polymorphisms in MMP2 promoter significantly influence transcriptional activity and their genotypes and haplotypes are associated with susceptibility to several cancers. This case-control study examined the contribution of these two polymorphisms to the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15731163
DOI: 10.1093/carcin/bgi057

Genes

MMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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