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Article

In vitro mutational spectrum of cyclopenta[cd]pyrene in the human HPRT gene.

Carcinogenesis - 1 Apr 1995

Keohavong P, Melacrinos A, Shukla R

Abstract excerpt

Cyclopenta[cd]pyrene (CPP) is a widely distributed polycyclic aromatic hydrocarbon with potent mutagenic and carcinogenic activity. In order to acquire an understanding of the mutagenic pathways of CPP, we studied mutations induced by this chemical in human cells. Four independent cultures of a human cell line expressing cytochrome P450 CYP1A1 (cell line MCL-5) were treated with CPP, and mutants at the...

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PMID: 7728967
DOI: 10.1093/carcin/16.4.855

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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