Article
In vitro mutational spectrum of cyclopenta[cd]pyrene in the human HPRT gene.
Carcinogenesis - 1 Apr 1995
Keohavong P, Melacrinos A, Shukla R
Abstract excerpt
Cyclopenta[cd]pyrene (CPP) is a widely distributed polycyclic aromatic hydrocarbon with potent mutagenic and carcinogenic activity. In order to acquire an understanding of the mutagenic pathways of CPP, we studied mutations induced by this chemical in human cells. Four independent cultures of a h...
Topics
- Base Sequence
- Carcinogens
- DNA
- DNA Mutational Analysis
- Densitometry
- Electrophoresis
- Exons
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Molecular Sequence Data
- Mutagens
- Mutation
- Nucleic Acid Denaturation
- Polymerase Chain Reaction
- Pyrenes