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The Effects of CKD on Cytochrome P450-Mediated Drug Metabolism.

Advances in chronic kidney disease - 1 Mar 2016

Ladda Matthew A, Goralski Kerry B

Abstract excerpt

CKD affects a significant proportion of the world's population, and the prevalence of CKD is increasing. Standard practice currently is to adjust the dose of renally eliminated medications as kidney function declines in effort to prevent adverse drug reactions. It is increasingly becoming recognized that CKD also impacts nonrenal clearance mechanisms such as hepatic and intestinal cytochrome P450 (CYP) enzymes...

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Identifiers

PMID: 26979145
DOI: 10.1053/j.ackd.2015.10.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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