Article

Spectrin-based Membrane Mechanics Is Asymmetric and Remodels during Neural Development

2020-04-29

Abstract excerpt

Perturbation of spectrin-based membrane mechanics causes hereditary elliptocytosis and spinocerebellar ataxia, but the underlying cellular basis of pathogenesis remains unclear. Here, we introduced the conserved disease-associated spectrin mutations into the C. elegans genome and studied the contribution of spectrin to neuronal migration and dendrite formation in developing larvae. The loss of spectrin generates...

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Literature Corpus work: 5f253015-fc9f-535d-9dfd-740e842f524b
DOI: 10.1101/2020.04.29.067975

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