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Article

BetaIV spectrins are essential for membrane stability and the molecular organization of nodes of Ranvier.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 18 Aug 2004

Yang Yang, Lacas-Gervais Sandra, Morest D Kent, Solimena Michele, Rasband Matthew N

Abstract excerpt

High densities of sodium channels at nodes of Ranvier permit action potential conduction and depend on betaIV spectrins, a family of scaffolding proteins linked to the cortical actin cytoskeleton. To investigate the molecular organization of nodes, we analyzed qv(3J)"quivering" mice, whose betaIV spectrins have a truncated proline-rich "specific" domain (SD) and lack the pleckstrin homology (PH) domain. Central...

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Identifiers

PMID: 15317849
DOI: 10.1523/JNEUROSCI.2125-04.2004
PMCID: PMC6729762

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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