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Article

BetaIV spectrins are essential for membrane stability and the molecular organization of nodes of Ranvier.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 18 Aug 2004

Yang Yang, Lacas-Gervais Sandra, Morest D Kent, Solimena Michele, Rasband Matthew N

Abstract excerpt

High densities of sodium channels at nodes of Ranvier permit action potential conduction and depend on betaIV spectrins, a family of scaffolding proteins linked to the cortical actin cytoskeleton. To investigate the molecular organization of nodes, we analyzed qv(3J)"quivering" mice, whose betaIV...

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Identifiers

PMID: 15317849
DOI: 10.1523/JNEUROSCI.2125-04.2004
PMCID: PMC6729762

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15317849-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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BetaIV spectrins are essential for membrane stability and the molecular organization of nodes of Ranvier.PMID 15317849Read ↗

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alphaII-spectrin is essential for assembly of the nodes of Ranvier in myelinated axons.Semantic proximity Read ↗

Postsynaptic β1 spectrin maintains Na+ channels at the neuromuscular junctionSemantic proximity Read ↗

[Beta]IV-spectrin regulates sodium channel clustering through ankyrin-G at axon initial segments and nodes of Ranvier.Semantic proximity Read ↗

βIV Spectrinopathies Cause Profound Intellectual Disability, Congenital Hypotonia, and Motor Axonal Neuropathy.Semantic proximity Read ↗

Reorganization of Destabilized Nodes of Ranvier in βIV Spectrin Mutants Uncovers Critical Timelines for Nodal Restoration and Prevention of Motor Paresis.Semantic proximity Read ↗

Giant ankyrin-G: a critical innovation in vertebrate evolution of fast and integrated neuronal signaling.Semantic proximity Read ↗

Specific role of the truncated betaIV-spectrin Sigma6 in sodium channel clustering at axon initial segments and nodes of ranvier.Semantic proximity Read ↗

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Mice lacking sodium channel beta1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture.Semantic proximity Read ↗

Spectrin βV adaptive mutations and changes in subcellular location correlate with emergence of hair cell electromotility in mammalians.Semantic proximity Read ↗

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