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Article

Schwann cell spectrins modulate peripheral nerve myelination.

Proceedings of the National Academy of Sciences of the United States of America - 10 May 2011

Susuki Keiichiro, Raphael Alya R, Ogawa Yasuhiro, Stankewich Michael C, Peles Elior, Talbot William S, Rasband Matthew N

Abstract excerpt

During peripheral nerve development, Schwann cells ensheathe axons and form myelin to enable rapid and efficient action potential propagation. Although myelination requires profound changes in Schwann cell shape, how neuron-glia interactions converge on the Schwann cell cytoskeleton to induce these changes is unknown. Here, we demonstrate that the submembranous cytoskeletal proteins αII and βII spectrin are...

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Identifiers

PMID: 21518878
DOI: 10.1073/pnas.1019600108
PMCID: PMC3093478

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