Article
Specific role of the truncated betaIV-spectrin Sigma6 in sodium channel clustering at axon initial segments and nodes of ranvier.
The Journal of biological chemistry - 2 Mar 2007
Uemoto Yoko, Suzuki So-Ichiro, Terada Nobuo, Ohno Nobuhiko, Ohno Shinichi, Yamanaka Shinya, Komada Masayuki
Abstract excerpt
At axon initial segments and nodes of Ranvier in neurons, the spectrin membrane skeleton plays roles in physically stabilizing the plasma membrane integrity and in clustering voltage-gated sodium channels for proper conduction of the action potential. betaIV-Spectrin, an essential component of the membrane skeleton at these sites, has an N-terminal-truncated isoform, Sigma6, which is expressed at much higher...
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