Article
Tumor response to radiotherapy is dependent on genotype-associated mechanisms in vitro and in vivo.
Radiation oncology (London, England) - 12 Aug 2010
Williams Jerry R, Zhang Yonggang, Zhou Haoming, Gridley Daila S, Koch Cameron J, Dicello John F, Slater James M, Little John B
Abstract excerpt
BACKGROUND: We have previously shown that in vitro radiosensitivity of human tumor cells segregate non-randomly into a limited number of groups. Each group associates with a specific genotype. However we have also shown that abrogation of a single gene (p21) in a human tumor cell unexpectedly sensitized xenograft tumors comprised of these cells to radiotherapy while not affecting in vitro cellular...
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