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Article

Abnormal promoter DNA hypermethylation of the integrin, nidogen, and dystroglycan genes in breast cancer.

Scientific reports - 26 Jan 2021

Strelnikov Vladimir V, Kuznetsova Ekaterina B, Tanas Alexander S, Rudenko Viktoria V, Kalinkin Alexey I, Poddubskaya Elena V, Kekeeva Tatiana V, Chesnokova Galina G, Trotsenko Ivan D, Larin Sergey S, Kutsev Sergey I, Zaletaev Dmitry V, Nemtsova Marina V, Simonova Olga A

Abstract excerpt

Cell transmembrane receptors and extracellular matrix components play a pivotal role in regulating cell activity and providing for the concerted integration of cells in the tissue structures. We have assessed DNA methylation in the promoter regions of eight integrin genes, two nidogen genes, and the dystroglycan gene in normal breast tissues and breast carcinomas (BC). The protein products of these genes interact...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33500458
DOI: 10.1038/s41598-021-81851-y
PMCID: PMC7838398

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