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Article

MORC 2 promotes development of an aggressive colorectal cancer phenotype through inhibition of NDRG 1

8 Nov 2018

Abstract excerpt

MORC2 (microrchidia family CW-type zinc finger 2) is a newly identified chromatin remodeling protein that functions in diverse biological processes including gene transcription. NDRG1 is a metastasis suppressor and a prognostic biomarker for colorectal cancer (CRC). However, the relationship between MORC2 and NDRG1 transcriptional regulation and the roles of MORC2 in CRC remain elusive. Here, we showed that MORC2...

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PMID: 30407715
DOI: 10.1111/cas.13863

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