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A transgenic zebrafish model of targeted oocyte ablation and de novo oogenesis

14 Jul 2011

Abstract excerpt

We describe here a novel transgenic zebrafish, Tg(zpc:G4VP16/UAS:nfsB-mCherry) that effectively demonstrates the targeted oocyte ablation in the adult zebrafish ovary. This transgenic line expresses bacterial nitroreductase enzyme (nfsB) under the control of the oocyte-specific zona pellucida C (zpc) gene promoter. Adult transgenic females exposed to the prodrug metronidazole demonstrated near-complete ablation...

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PMID: 21761478
DOI: 10.1002/dvdy.22695

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