Article
Isoform-specific and protein kinase C-mediated regulation of CTP:phosphoethanolamine cytidylyltransferase phosphorylation.
The Journal of biological chemistry - 28 Mar 2014
Pavlovic Zvezdan, Zhu Lin, Pereira Leanne, Singh Ratnesh Kumar, Cornell Rosemary B, Bakovic Marica
Abstract excerpt
CTP:phosphoethanolamine cytidylyltransferase (Pcyt2) is the main regulatory enzyme for de novo biosynthesis of phosphatidylethanolamine by the CDP-ethanolamine pathway. There are two isoforms of Pcyt2, -α and -β; however, very little is known about their specific roles in this important metabolic pathway. We previously demonstrated increased phosphatidylethanolamine biosynthesis subsequent to elevated activity...
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