Article
A novel tetracyclic peptide, trapoxin, induces phenotypic change from transformed to normal in sis-oncogene-transformed NIH3T3 cells.
Japanese journal of cancer research : Gann - 1 Apr 1992
Yoshida H, Sugita K
Abstract excerpt
A novel tetracyclic peptide, trapoxin [cyclo(L-phenylalanyl-L-phenylalanyl-D-pipecolinyl-L-2-amino-8-oxo -9,10-epoxy - decanoyl)], was found to induce the flat phenotype in v-sis-transformed NIH3T3 cells at a quite low concentration of 1 ng/ml. Actin stress fiber could be detected after trapoxin...
Topics
- 3T3 Cells
- Actins
- Animals
- Anti-Bacterial Agents
- Antibiotics, Antineoplastic
- Cell Transformation, Neoplastic
- Kinetics
- Mice
- Oncogene Proteins v-sis
- Oncogenes
- Peptides
- Peptides, Cyclic
- Phenotype
- RNA, Messenger
- Retroviridae Proteins, Oncogenic