Article
A multifunctional transcription factor (A1p145) regulates the smooth muscle phenotype in mesangial cells.
Biochemical and biophysical research communications - 18 Nov 1998
Takeoka H, Iehara N, Uematsu-Yanagita M, Abe H, Sunamoto M, Yamada Y, Kita T, Doi T
Abstract excerpt
A1p145, a novel DNA binding protein for type IV collagen gene (COL4), has multiple functions including DNA replication factor C and DNA binding for several other genes. To elucidate the mechanisms underlying the differentiation process of mesangial cells (MCs), we investigated the effects of A1p145 on rat MCs. Cells in the early passages showed a smooth muscle-like phenotype such as low cell turnover, high levels...
Topics
- Actins
- Animals
- Base Sequence
- Cell Differentiation
- Cells, Cultured
- Collagen
- DNA
- DNA Methylation
- DNA Primers
- Gene Expression Regulation
- Glomerular Mesangium
- Muscle, Smooth
- Oligodeoxyribonucleotides, Antisense
- Phenotype