Article
Impact of HIV-1 reverse transcriptase polymorphism at codons 211 and 228 on virological response to didanosine.
Antiviral therapy - 1 Jan 2006
Marcelin Anne-Genevieve, Flandre Philippe, Furco Andre, Wirden Marc, Molina Jean-Michel, Calvez Vincent
Abstract excerpt
OBJECTIVE: To determine the potential impact of reverse transcriptase (RT) mutations, other than those currently known to confer nucleoside reverse transcriptase inhibitors (NRTIs) resistance, on the virological response to didanosine (ddl). DESIGN AND PATIENTS: In the placebo-controlled Jaguar trial, 168 patients were randomly assigned to receive ddl (n=111) or placebo (n=57) in addition to their currently...
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