Article
An additive/subtractive genotypic score as a determinant of the virological response to didanosine in HIV-1 infected patients.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 May 2006
Capdepont Sophie, Aurillac-Lavignolle Valérie, Faure Muriel, Dupon Michel, Morlat Philippe, Ragnaud Jean-Marie, Chêne Geneviève, Fleury Hervé, Masquelier Bernard
Abstract excerpt
OBJECTIVE: To assess the genotypic determinants of the virological response (VR) to didanosine (ddI) in nucleoside reverse transcriptase inhibitors (NRTI)-experienced patients. METHODS: Human immunodeficiency virus type 1 (HIV-1) genotype was determined at baseline in 74 ddI-naive-patients with baseline viral load >500 copies/ml and receiving ddI as part of a new regimen. VR was defined as a plasma HIV-1 RNA <50...
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