Article
Clinically relevant genotype interpretation of resistance to didanosine.
Antimicrobial agents and chemotherapy - 1 May 2005
Marcelin Anne-Geneviève, Flandre Philippe, Pavie Juliette, Schmidely Nathalie, Wirden Marc, Lada Olivier, Chiche Dan, Molina Jean-Michel, Calvez Vincent
Abstract excerpt
We analyzed the didanosine (ddI) arm of the randomized, placebo-controlled Jaguar trial in order to define a genotypic score for ddI associated with virologic response. In this arm, 111 patients experiencing virologic failure received ddI in addition to their current combination therapy for 4 weeks. The impact of mutations in the reverse transcriptase gene on the virologic response to ddI was studied in...
Topics
- Adult
- Aged
- Algorithms
- Anti-HIV Agents
- Data Interpretation, Statistical
- Didanosine
- Double-Blind Method
- Drug Resistance, Viral
- Female
- Genotype
- HIV Infections
- HIV Reverse Transcriptase
- HIV-1
- Humans