Article
Development of a didanosine genotypic resistance interpretation system based on large derivation and validation datasets.
AIDS (London, England) - 28 Jan 2010
Assoumou Lambert, Cozzi-Lepri Alessandro, Brun-Vézinet Françoise, Degruttola Victor, Kuritzkes Daniel R, Phillips Andrew, Zolopa Andrew, Miller Veronica, Flandre Philippe, Costagliola Dominique
Abstract excerpt
OBJECTIVE: To assess the genotypic determinants of the virological response to didanosine (ddI) in HIV-infected patients. METHODS: The Forum database on ddI was randomly divided into a derivation set (n = 1000) and a validation set (n = 453). Linear regression models and bootstrap sampling were used to select resistance mutations and to estimate their resistance scores. Linear regression models, accounted for the...
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