Article
The influence of the M184V mutation in HIV-1 reverse transcriptase on the virological outcome of highly active antiretroviral therapy regimens with or without didanosine.
Antiviral therapy - 1 Jan 2005
Sproat Michael, Pozniak Anton L, Peeters Monika, Winters Bart, Hoetelmans Richard, Graham Neil M, Gazzard Brian G
Abstract excerpt
BACKGROUND: In vitro phenotypic resistance studies suggest that the presence of the M184V mutation leads to a reduction in HIV-1 susceptibility to didanosine (ddl). The relevance of this to clinical outcomes remains unclear. In this study, we compared the virological response of ddl- and non-ddl-...
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