Modulation of the invasive phenotype of human colon carcinoma cells by organ specific fibroblasts of nude mice.

doi:10.1111/j.1432-0436.1992.tb00504.x

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Article

Modulation of the invasive phenotype of human colon carcinoma cells by organ specific fibroblasts of nude mice.

Differentiation; research in biological diversity - 1 Dec 1992

Fabra A, Nakajima M, Bucana C D, Fidler I J

Abstract excerpt

We examined whether fibroblasts from subcutaneous, colon or lung tissues of nude mice influence the invasive potential of highly metastatic human colon carcinoma KM12SM cells. Primary cultures of nude mouse fibroblasts from skin, lung and colon were established. Invasive and metastatic KM12SM cells were cultured alone or with fibroblasts. Growth and invasive properties of the KM12SM cells were evaluated as well...

Topics

Animals
Carcinoma
Cell Division
Collagenases
Colon
Colonic Neoplasms
Fibroblasts
Humans
Lung
Matrix Metalloproteinase 9
Mice
Mice, Nude

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microscopy, Electron, Scanning

Neoplasm Invasiveness

Organ Specificity

Phenotype

Skin

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 1286773
DOI: 10.1111/j.1432-0436.1992.tb00504.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1286773-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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