Article
Loss of epithelial differentiation markers and acquisition of vimentin expression after xenograft with laminin-1 enhance migratory and invasive abilities of human colon cancer cells LoVo C5.
Differentiation; research in biological diversity - 1 Jul 1998
Dumortier J, Daemi N, Pourreyron C, Anderson W, Bellaton C, Jacquier M F, Bertrand S, Chayvialle J A, Remy L
Abstract excerpt
Clone C5 of the human colon adenocarcinoma LoVo cell line was subcutaneously injected with or without exogenous laminin-1 (EHS laminin) into immunosuppressed newborn rats. Cultures were initiated from lung metastases obtained with or without laminin-1 and gave rise to the C5 sublines LM and M4, r...
Topics
- Adenocarcinoma
- Animals
- Cell Differentiation
- Cell Movement
- Collagenases
- Colonic Neoplasms
- Epithelial Cells
- Gelatinases
- Humans
- Laminin
- Matrix Metalloproteinase 2
- Matrix Metalloproteinase 9
- Metalloendopeptidases