Article
Loss of epithelial differentiation markers and acquisition of vimentin expression after xenograft with laminin-1 enhance migratory and invasive abilities of human colon cancer cells LoVo C5.
Differentiation; research in biological diversity - 1 Jul 1998
Dumortier J, Daemi N, Pourreyron C, Anderson W, Bellaton C, Jacquier M F, Bertrand S, Chayvialle J A, Remy L
Abstract excerpt
Clone C5 of the human colon adenocarcinoma LoVo cell line was subcutaneously injected with or without exogenous laminin-1 (EHS laminin) into immunosuppressed newborn rats. Cultures were initiated from lung metastases obtained with or without laminin-1 and gave rise to the C5 sublines LM and M4, respectively. The LM subline was mainly composed of spreading cells whereas most C5 and M4 cells remained round and...
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