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Article

Role of focal adhesion kinase Ser-732 phosphorylation in centrosome function during mitosis.

The Journal of biological chemistry - 3 Apr 2009

Park Ann Y J, Shen Tang-Long, Chien Shu, Guan Jun-Lin

Abstract excerpt

Focal adhesion kinase (FAK) is the major cytoplasmic tyrosine kinase in focal adhesions and a critical mediator of integrin signaling in a variety of cells, including endothelial cells (ECs). Here we describe a new function for FAK in the regulation of centrosome functions in a Ser-732 phosphorylation-dependent manner during mitosis. Deletion of FAK in primary ECs causes increases in centrosome numbers,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19201755
DOI: 10.1074/jbc.M809040200
PMCID: PMC2666594

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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