Article
Common genetic variation in TP53 is associated with lung cancer risk and prognosis in African Americans and somatic mutations in lung tumors.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Feb 2007
Mechanic Leah E, Bowman Elise D, Welsh Judith A, Khan Mohammed A, Hagiwara Nobutoshi, Enewold Lindsey, Shields Peter G, Burdette Laurie, Chanock Stephen, Harris Curtis C
Abstract excerpt
Lung cancer is primarily caused by tobacco smoking, but susceptibility is likely modified by common genetic variation. In response to many forms of cellular stress, including DNA damage, the p53 protein functions to induce cell cycle arrest, DNA repair, senescence, or apoptosis. We hypothesized that common TP53 haplotypes modulate pathways of lung carcinogenesis and lung cancer susceptibility or prognosis. To...
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