Article
p53 Genotypes and Haplotypes Associated With Lung Cancer Susceptibility and Ethnicity.
Journal of the National Cancer Institute - 1 May 2002
Wu Xifeng, Zhao Hua, Amos Christopher I, Shete Sanjay, Makan Nimisha, Hong Waun K, Kadlubar Fred F, Spitz Margaret R
Abstract excerpt
BACKGROUND: The p53 tumor suppressor protein is important in cell-cycle control, apoptosis, and DNA repair. Mutations in p53 have been associated with inherited cancer susceptibility. Because there is a difference in the risk of lung cancer among different ethnic groups, we examined associations between ethnicity and three polymorphisms in p53 (one exonic and two intronic) and haplotypes for the three loci and...
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