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Article

Allelic variation in RGS4 impacts functional and structural connectivity in the human brain.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 14 Feb 2007

Buckholtz Joshua W, Meyer-Lindenberg Andreas, Honea Robyn A, Straub Richard E, Pezawas Lukas, Egan Michael F, Vakkalanka Radhakrishna, Kolachana Bhaskar, Verchinski Beth A, Sust Steven, Mattay Venkata S, Weinberger Daniel R, Callicott Joseph H

Abstract excerpt

Regulator of G-protein signaling 4 (RGS4) modulates postsynaptic signal transduction by affecting the kinetics of G alpha-GTP binding. Linkage, association, and postmortem studies have implicated the gene encoding RGS4 (RGS4) as a schizophrenia susceptibility factor. Using a multimodal neuroimaging approach, we demonstrate that genetic variation in RGS4 is associated with functional activation and connectivity...

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Identifiers

PMID: 17301167
DOI: 10.1523/JNEUROSCI.5112-06.2007
PMCID: PMC6673752

Genes

RGS4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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