Article
Ethnic stratification of the association of RGS4 variants with antipsychotic treatment response in schizophrenia.
Biological psychiatry - 1 Jan 2008
Campbell Daniel B, Ebert Philip J, Skelly Tara, Stroup T Scott, Lieberman Jeffrey, Levitt Pat, Sullivan Patrick F
Abstract excerpt
BACKGROUND: Genetic association studies, including a large meta-analysis, report association of regulator of G protein signaling 4 (RGS4) with schizophrenia in the context of heterogeneity. The central role of RGS4 in regulating signaling via Gi/o coupled neurotransmitter receptors led us to hypothesize that there may be RGS4 genotypes predictive of specific disease phenotypes and antipsychotic treatment...
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