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Article

The significance of C3435T point mutation of the MDR1 gene in endometrial cancer.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society - 1 Jan 2000

Mrozikiewicz P M, Seremak-Mrozikiewicz A, Semczuk A, Landt O, Breborowicz G H, Drews K

Abstract excerpt

The P-glycoprotein (P-gp) plays an important role in carcinogen distribution and is connected with cell differentiation and apoptotic processes leading to carcinogenesis. Interindividual differences in P-gp activity could modulate susceptibility to cancer development. The MDR1 gene, coding for P-gp, is highly polymorphic and some mutations modulate P-gp activity. Recently, association between the MDR1 C3435T...

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Source

Identifiers

PMID: 17300681
DOI: 10.1111/j.1525-1438.2007.00821.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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