Article
Computational analysis of the synergy among multiple interacting genes.
Molecular systems biology - 1 Jan 2007
Anastassiou Dimitris
Abstract excerpt
Diseases such as cancer are often related to collaborative effects involving interactions of multiple genes within complex pathways, or to combinations of multiple SNPs. To understand the structure of such mechanisms, it is helpful to analyze genes in terms of the purely cooperative, as opposed to independent, nature of their contributions towards a phenotype. Here, we present an information-theoretic analysis...
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