Article
Identification of gene interactions associated with disease from gene expression data using synergy networks.
BMC systems biology - 30 Jan 2008
Watkinson John, Wang Xiaodong, Zheng Tian, Anastassiou Dimitris
Abstract excerpt
BACKGROUND: Analysis of microarray data has been used for the inference of gene-gene interactions. If, however, the aim is the discovery of disease-related biological mechanisms, then the criterion for defining such interactions must be specifically linked to disease. RESULTS: Here we present a computational methodology that jointly analyzes two sets of microarray data, one in the presence and one in the absence...
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