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Article

A partial GDNF depletion leads to earlier age-related deterioration of motor function and tyrosine hydroxylase expression in the substantia nigra.

Experimental neurology - 1 Dec 2006

Boger H A, Middaugh L D, Huang P, Zaman V, Smith A C, Hoffer B J, Tomac A C, Granholm A-Ch

Abstract excerpt

Glial cell line-derived neurotrophic factor (GDNF) is a trophic factor for peripheral organs, spinal cord, and midbrain dopamine (DA) neurons. Levels of GDNF deteriorate in the substantia nigra in Parkinson's disease (PD). A heterozygous mouse model was created to assess whether chronic reductions in this neurotrophic factor impact motor function and the nigrostriatal dopamine system during the aging process. Due...

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Source

Identifiers

PMID: 16889771
DOI: 10.1016/j.expneurol.2006.06.006

Genes

GDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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