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Article

An S6 mutation in BK channels reveals beta1 subunit effects on intrinsic and voltage-dependent gating.

The Journal of general physiology - 1 Dec 2006

Wang Bin, Brenner Robert

Abstract excerpt

Large conductance, Ca(2+)- and voltage-activated K(+) (BK) channels are exquisitely regulated to suit their diverse roles in a large variety of physiological processes. BK channels are composed of pore-forming alpha subunits and a family of tissue-specific accessory beta subunits. The smooth muscle-specific beta1 subunit has an essential role in regulating smooth muscle contraction and modulates BK channel...

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Identifiers

PMID: 17130522
DOI: 10.1085/jgp.200609596
PMCID: PMC2151602

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