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Article

Sept4, a component of presynaptic scaffold and Lewy bodies, is required for the suppression of alpha-synuclein neurotoxicity.

Neuron - 15 Feb 2007

Ihara Masafumi, Yamasaki Nobuyuki, Hagiwara Akari, Tanigaki Ai, Kitano Ayumi, Hikawa Rie, Tomimoto Hidekazu, Noda Makoto, Takanashi Masashi, Mori Hideo, Hattori Nobutaka, Miyakawa Tsuyoshi, Kinoshita Makoto

Abstract excerpt

In Parkinson disease (PD), alpha-synuclein aggregates called Lewy bodies often involve and sequester Septin4 (Sept4), a polymerizing scaffold protein. However, the pathophysiological significance of this phenomenon is unclear. Here, we show the physiological association of Sept4 with alpha-synucl...

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Identifiers

PMID: 17296554
DOI: 10.1016/j.neuron.2007.01.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17296554-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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