Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of Lewy body protein septin 4 in postmortem brain of Parkinson's disease and control subjects

24 Oct 2008

Abstract excerpt

In Parkinson's disease (PD) neuronal degeneration is associated with abnormal protein aggregation in various forms including Lewy bodies (LBs). A major component of LBs is alpha-synuclein; septin 4 (SEPT4), a polymerizing GTP-binding protein that serves as scaffold for diverse molecules has been found to colocalize with alpha-synuclein in LBs. The central role of SEPT4 in the etiopathogenesis of PD has been...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Neurodegenerative Diseases
Share to Neurological diseases and metabolism
Share to Parkinson's Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18951507
DOI: 10.1002/mds.22306

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of Lewy body protein septin 4 in postmortem brain of Parkinson's disease and control subjectsPMID 18951507Read ↗

Sept4, a component of presynaptic scaffold and Lewy bodies, is required for the suppression of alpha-synuclein neurotoxicity.Semantic proximity Read ↗

SEPT14 Is Associated with a Reduced Risk for Parkinson's Disease and Expressed in Human Brain.Semantic proximity Read ↗

Altered α‐synuclein, parkin, and synphilin isoform levels in multiple system atrophy brainsSemantic proximity Read ↗

Septin 4, the drosophila ortholog of human CDCrel-1, accumulates in parkin mutant brains and is functionally related to the Nedd4 E3 ubiquitin ligase.Semantic proximity Read ↗

Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies.Semantic proximity Read ↗

Overexpression of Septin 4, the Drosophila homologue of human CDCrel-1, is toxic for dopaminergic neurons.Semantic proximity Read ↗

Periphilin is a novel interactor of synphilin-1, a protein implicated in Parkinson's disease.Semantic proximity Read ↗

Parkin and synphilin-1 isoform expression changes in Lewy body diseases.Semantic proximity Read ↗

Pael‐R is accumulated in Lewy bodies of Parkinson's diseaseSemantic proximity Read ↗

Platelet miRNAs as early biomarkers for progression of idiopathic REM sleep behavior disorder to a synucleinopathySemantic proximity Read ↗

Preliminary Findings on Proline-Rich Protein 14 as a Diagnostic Biomarker for Parkinson's Disease.Semantic proximity Read ↗

α-synuclein phosphorylation and truncation are normal events in the adult human brain.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.