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Article

Overexpression of Septin 4, the Drosophila homologue of human CDCrel-1, is toxic for dopaminergic neurons.

The European journal of neuroscience - 1 Dec 2007

Muñoz-Soriano Verónica, Paricio Nuria

Abstract excerpt

parkin loss-of-function mutations are linked to autosomal recessive juvenile parkinsonism. Parkin is an E3 ubiquitin ligase that promotes degradation of specific target proteins by the proteasome. It has been proposed that loss of Parkin activity will result in accumulation of its substrates, thu...

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Identifiers

PMID: 18028112
DOI: 10.1111/j.1460-9568.2007.05937.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18028112-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Overexpression of Septin 4, the Drosophila homologue of human CDCrel-1, is toxic for dopaminergic neurons.PMID 18028112Read ↗

Septin 4, the drosophila ortholog of human CDCrel-1, accumulates in parkin mutant brains and is functionally related to the Nedd4 E3 ubiquitin ligase.Semantic proximity Read ↗

Drosophila melanogaster Parkin ubiquitinates peanut and septin1 as an E3 ubiquitin-protein ligase.Semantic proximity Read ↗

Parkin negatively regulates JNK pathway in the dopaminergic neurons of Drosophila.Semantic proximity Read ↗

Analysis of α-syn and parkin interaction in mediating neuronal death in Drosophila model of Parkinson's diseaseSemantic proximity Read ↗

The Down syndrome candidate dual-specificity tyrosine phosphorylation-regulated kinase 1A phosphorylates the neurodegeneration-related septin 4.Semantic proximity Read ↗

Identifying potential PARIS homologs in D. melanogaster.Semantic proximity Read ↗

Absence of pretaporter restrains features of the parkin phenotype in Drosophila.Semantic proximity Read ↗

Parkin functions as an E2-dependent ubiquitin– protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1Semantic proximity Read ↗

Parkin R274W mutation affects muscle and mitochondrial physiology.Semantic proximity Read ↗

A Drosophila model of mutant human parkin-induced toxicity demonstrates selective loss of dopaminergic neurons and dependence on cellular dopamine.Semantic proximity Read ↗

Characterization of a Cul9-Parkin double knockout mouse model for Parkinson's disease.Semantic proximity Read ↗

Sept4, a component of presynaptic scaffold and Lewy bodies, is required for the suppression of alpha-synuclein neurotoxicity.Semantic proximity Read ↗

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