Article
(-)-Adrenaline elicits positive inotropic, lusitropic, and biochemical effects through beta2 -adrenoceptors in human atrial myocardium from nonfailing and failing hearts, consistent with Gs coupling but not with Gi coupling.
Naunyn-Schmiedeberg's archives of pharmacology - 1 Mar 2007
Molenaar Peter, Savarimuthu Santiyagu M, Sarsero Doreen, Chen Lu, Semmler Annalese B T, Carle Anne, Yang Ian, Bartel Sabine, Vetter Donate, Beyerdörfer Inge, Krause Ernst-Georg, Kaumann Alberto J
Abstract excerpt
Activation of either coexisting beta1- or beta2 -adrenoceptors with noradrenaline or adrenaline, respectively, causes maximum increases of contractility of human atrial myocardium. Previous biochemical work with the beta2 -selective agonist zinterol is consistent with activation of the cascade beta2 -adrenoceptors-->Gsalpha-protein-->adenylyl cyclase-->cAMP-->protein kinase (PKA)-->phosphorylation of...
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