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Article

Caspase-11 regulates cell migration by promoting Aip1-Cofilin-mediated actin depolymerization.

Nature cell biology - 1 Mar 2007

Li Juying, Brieher William M, Scimone M Lucila, Kang Shin Jung, Zhu Hong, Yin Helen, von Andrian Ulrich H, Mitchison Timothy, Yuan Junying

Abstract excerpt

Coordinated regulation of cell migration, cytokine maturation and apoptosis is critical in inflammatory responses. Caspases, a family of cysteine proteases, are known to regulate cytokine maturation and apoptosis. Here, we show that caspase-11, a mammalian pro-inflammatory caspase, regulates cell migration during inflammation. Caspase-11-deficient lymphocytes exhibit a cell-autonomous migration defect in vitro...

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Identifiers

PMID: 17293856
DOI: 10.1038/ncb1541

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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