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Identification of transcriptional regulators in the mouse immune system.

1 Jun 2013

Abstract excerpt

The differentiation of hematopoietic stem cells into cells of the immune system has been studied extensively in mammals, but the transcriptional circuitry that controls it is still only partially understood. Here, the Immunological Genome Project gene-expression profiles across mouse immune lineages allowed us to systematically analyze these circuits. To analyze this data set we developed Ontogenet, an algorithm...

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PMID: 23624555
DOI: 10.1038/ni.2587

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