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Article

Differential regulation of progranulin derived granulin peptides

4 Feb 2022

Abstract excerpt

BACKGROUND: Haploinsufficiency of progranulin (PGRN) is a leading cause of frontotemporal lobar degeneration (FTLD). PGRN is comprised of 7.5 granulin repeats and is processed into individual granulin peptides in the lysosome. However, very little is known about the levels and regulations of individual granulin peptides due to the lack of specific antibodies. RESULTS: Here we report the generation and...

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PMID: 35120524
DOI: 10.1186/s13024-021-00513-9

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