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Article

Reversal of neurological defects in a mouse model of Rett syndrome.

Science (New York, N.Y.) - 23 Feb 2007

Guy Jacky, Gan Jian, Selfridge Jim, Cobb Stuart, Bird Adrian

Abstract excerpt

Rett syndrome is an autism spectrum disorder caused by mosaic expression of mutant copies of the X-linked MECP2 gene in neurons. However, neurons do not die, which suggests that this is not a neurodegenerative disorder. An important question for future therapeutic approaches to this and related d...

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Source

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Identifiers

PMID: 17289941
DOI: 10.1126/science.1138389
PMCID: PMC7610836

Genes

MECP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17289941-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Reversal of neurological defects in a mouse model of Rett syndrome.PMID 17289941Read ↗

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Rett syndrome treatment in mouse models: searching for effective targets and strategies.Semantic proximity Read ↗

Tsix-Mecp2 female mouse model for Rett syndrome reveals that low-level MECP2 expression extends life and improves neuromotor function.Semantic proximity Read ↗

Mouse models of Rett syndrome: from behavioural phenotyping to preclinical evaluation of new therapeutic approaches.Semantic proximity Read ↗

Deciphering MECP2-associated disorders: disrupted circuits and the hope for repair.Semantic proximity Read ↗

Sex differences in Mecp2-mutant Rett syndrome model mice and the impact of cellular mosaicism in phenotype development.Semantic proximity Read ↗

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Acute and crucial requirement for MeCP2 function upon transition from early to late adult stages of brain maturation.Semantic proximity Read ↗

Mice with an isoform-ablating Mecp2 exon 1 mutation recapitulate the neurologic deficits of Rett syndromeSemantic proximity Read ↗

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