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Article

Reversal of neurological defects in a mouse model of Rett syndrome.

Science (New York, N.Y.) - 23 Feb 2007

Guy Jacky, Gan Jian, Selfridge Jim, Cobb Stuart, Bird Adrian

Abstract excerpt

Rett syndrome is an autism spectrum disorder caused by mosaic expression of mutant copies of the X-linked MECP2 gene in neurons. However, neurons do not die, which suggests that this is not a neurodegenerative disorder. An important question for future therapeutic approaches to this and related disorders concerns phenotypic reversibility. Can viable but defective neurons be repaired, or is the damage done during...

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Source

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Identifiers

PMID: 17289941
DOI: 10.1126/science.1138389
PMCID: PMC7610836

Genes

MECP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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