Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Influence of factor V HR2 on thrombin generation and clinical manifestation in rare bleeding disorders.

Pathophysiology of haemostasis and thrombosis - 1 Jan 2005

Strey Rüdiger F, Siegemund Annelie, Siegemund Thomas, Schubert Christine, Schuster Gudrun, Wulff Karin, Herrmann Falko H

Abstract excerpt

In this study we investigated the influence of the presence of the factor V HR2 haplotype, defined by the factor V gene mutation H1299R (FV(HR2)), on thrombin generation. Measurements were performed in platelet-poor plasma of individuals with factor V(HR2) or factor V(Leiden) in comparison to a control group carrying none of these mutations. Coagulation was triggered by low concentrations of recombinant tissue...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Coagulation Disorders
Share to Factor V

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Haplotypes

Share to Heterozygote

Share to Homozygote

Share to Risk Factors

Share to Thrombin

Source

Identifiers

PMID: 16772740
DOI: 10.1159/000093108

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Influence of factor V HR2 on thrombin generation and clinical manifestation in rare bleeding disorders.PMID 16772740Read ↗

Increased factor VIII coagulant activity levels in male carriers of the factor V R2 polymorphism.Semantic proximity Read ↗

Coagulation factor V G allele and HR2 haplotype: factor V activity, activated protein C resistance and risk of venous thrombosis.Semantic proximity Read ↗

FV HR2 haplotype as additional inherited risk factor for deep vein thrombosis in individuals with a high-risk profile.Semantic proximity Read ↗

The HR2 haplotype of factor V: effects on factor V levels, normalized activated protein C sensitivity ratios and the risk of venous thrombosis.Semantic proximity Read ↗

Factor V HR2 haplotype: a risk factor for venous thromboembolism in individuals with absence of Factor V Leiden.Semantic proximity Read ↗

Prevalence of factor V R2 (H1299R) polymorphism in the Lebanese population.Semantic proximity Read ↗

Association of factor V deficiency with factor V HR2.Semantic proximity Read ↗

Factor-V HR2 haplotype and thromboembolic disease.Semantic proximity Read ↗

Clinical studies and thrombin generation in patients homozygous or heterozygous for the G20210A mutation in the prothrombin gene.Semantic proximity Read ↗

Investigation of genotype-dependent differences in factor V activity as well as response to activated protein C by application of different methods.Semantic proximity Read ↗

Coinheritance of the HR2 haplotype in the factor V gene confers an increased risk of venous thromboembolism to carriers of factor V R506Q (factor V Leiden).Semantic proximity Read ↗

The factor V (FV) gene ASP79HIS polymorphism modulates FV plasma levels and affects the activated protein C resistance phenotype in presence of the FV Leiden mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.